| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
miR-124 |
| Biological function: |
prognostic biomarker for lower risk of progression |
| Molecular mechanism: |
Enriched miRNA target sites and SCEs, but no evidence for repeated binding sites for the same miRNA (argues against miRNA sponge as canonical mechanism). |
| Biological pathway or process: |
ceRNA regulation (other) |
| Detected method: |
S
|
| Validation methods: |
RNA-seq; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; Nuclear-Cytoplasmic Fractionation; Survival Analysis; Clinical Sample Validation |
| Clinical significance: |
High circHIPK3 expression is associated with a significantly lower risk of progression in NMIBC (independent of the linear transcript and host gene). |
| Description: |
circHIPK3 is upregulated in the less aggressive NMIBC risk class and higher expression predicts a lower risk of progression independently of the linear transcript and host gene. It is mainly localized in the cytoplasm and shows enrichment of miRNA target sites/SCEs, but the study does not support a strong single-miRNA sponge mechanism. |
| Confidence score: |
0.63 |