circRNA basic information
circBase ID: hsa_circ_0000594
Name: hsa_circ_TTBK2
Synonym: circ-TTBK2
Host Gene: TTBK2
Genomic location(hg19): chr15:43120125-43164956:-
Genomic location(hg38): chr15:42827927-42872758:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0021042
MONDO name: glioma
Disease details: glioma
Disease DO ID:
 -
Disease MeSH ID:
 D005910
Disease NCIt ID:
 C3059
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

glioma tissues; normal brain tissues
Cell lines:

NHA; T98G; U251
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: CHD1
Associated microRNA: miR-1283
Biological function: Promotes glioma cell proliferation, migration, invasion and glycolysis; enhances xenograft tumor growth.
Molecular mechanism: Acts as a ceRNA/miRNA sponge for miR-1283 to regulate CHD1 expression.
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); glycolysis (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Transfection; MTT; Transwell Assay; Luciferase Reporter Assay; Western Blot; In Vivo Animal Model; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

-
Description:

circ-TTBK2 is up-regulated in glioma tissues and cell lines and promotes malignant phenotypes including proliferation, migration, invasion and glycolysis. Mechanistically, circ-TTBK2 acts as a ceRNA by sponging miR-1283 to increase CHD1, and its knockdown suppresses tumor growth in a U251 xenograft model.
Confidence score:

0.7581
Other information
Title:

Knockdown of circ-TTBK2 Inhibits Glioma Progression by Regulating miR-1283 and CHD1.

Journal: Cancer management and research
Published: 2020
PubMed ID: 33116862
Study type:

combined biological and clinical study
Data availability: -
Code availability: -