circRNA basic information
circBase ID: hsa_circ_0001666
Name: hsa_circ_FAM120B
Synonym: -
Host Gene: FAM120B
Genomic location(hg19): chr6:170626457-170639638:+
Genomic location(hg38): chr6:170317369-170330550:+
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer
Disease DO ID:
5672, 9256
Disease MeSH ID:
-
Disease NCIt ID:
C4978
Disease ICD11 ID:
-
Disease OMIM ID:
114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

colorectal cancer tissues; matched normal tissues; paracancerous tissues

Cell lines:

LoVo; DLD-1; Caco-2; SW480; HCT-116; SW620; HT-29; NCM460; HEK-293T

In vivo animal model:

cell line-derived xenograft

circRNA-disease information
Expression pattern:
DN
Associated gene: PCDH10, AGO2
Associated microRNA: miR-576-5p
Biological function: Suppresses CRC progression by inhibiting proliferation, migration/invasion, metastasis, EMT and stemness, and promoting apoptosis.
Molecular mechanism: Acts as a ceRNA/miRNA sponge for miR-576-5p to relieve repression of PCDH10, thereby inhibiting Wnt/beta-catenin signaling and EMT/stemness.
Biological pathway or process:

Wnt/beta-catenin (inhibits); proliferation (inhibits); apoptosis (promotes); migration (inhibits); invasion (inhibits); metastasis (inhibits); EMT (inhibits); stemness (inhibits); ceRNA regulation (other)

Detected method:
Q
M
Validation methods:

Microarray; Bioinformatics Analysis; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RNase R Treatment; FISH / smFISH; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; EdU Staining; Annexin V/PI Flow Cytometry; Transwell Assay; Wound Healing Assay; In Vivo Animal Model; IHC (Immunohistochemistry); H&E Staining; Western Blot; Survival Analysis

Clinical significance:

Higher hsa_circ_0001666 expression indicates better overall survival and is associated with lower TNM stage, less lymph node invasion and smaller tumour size.

Description:

In colorectal cancer, hsa_circ_0001666 is down-regulated and functions as a tumor suppressor. It sponges miR-576-5p to de-repress PCDH10, thereby inhibiting Wnt/beta-catenin signaling, EMT/stemness, proliferation and metastasis while promoting apoptosis. Higher expression is associated with better patient survival.

Confidence score:

0.8748

Other information
Title:

Hsa_circ_0001666 suppresses the progression of colorectal cancer through the miR-576-5p/PCDH10 axis.

Journal: Clinical and translational medicine
Published: 2021
PubMed ID: 34841662
Study type:

combined biological and clinical study

Data availability: GSE126094
Code availability: -