| Expression pattern: |
UP |
| Associated gene: |
Ago2 |
| Associated microRNA: |
miR-1286 |
| Biological function: |
promotes migration, invasion, EMT, and pulmonary metastasis of cervical cancer cells; promotes proliferation/viability |
| Molecular mechanism: |
circ_PVT1 sponges miR-1286 and is delivered via exosomes to induce EMT |
| Biological pathway or process: |
EMT (promotes); metastasis (promotes); migration (promotes); invasion (promotes); proliferation (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; FISH / smFISH; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Western Blot; IF (Immunofluorescence); In Vivo Animal Model |
| Clinical significance: |
circ_PVT1 is elevated in plasma and urine exosomes from cervical cancer patients versus healthy volunteers |
| Description: |
circ_PVT1 (hsa_circ_0009143) is up-regulated in cervical cancer tissues/cells and in patient plasma/urine exosomes. Functionally, it promotes proliferation, migration, invasion, EMT and lung metastasis. Mechanistically, it acts as a miR-1286 sponge and can be transmitted via exosomes to activate EMT in recipient cells. |
| Confidence score: |
0.6791 |