| Expression pattern: |
UP |
| Associated gene: |
HOXA9 |
| Associated microRNA: |
miR-604 |
| Biological function: |
Promotes colorectal cancer cell proliferation, migration, and invasion; silencing inhibits malignant progression. |
| Molecular mechanism: |
Acts as a molecular sponge for miR-604 to regulate HOXA9 (circ_0052184/miR-604/HOXA9 regulatory network). |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Bioinformatics Analysis; Western Blot |
| Clinical significance: |
circ_0052184 may be a therapeutic target for CRC and a potential biomarker for CRC diagnosis. |
| Description: |
circ_0052184 is up-regulated in colorectal cancer tissues and cell lines and promotes CRC cell proliferation, migration, and invasion. Mechanistically, it functions as a ceRNA by sponging miR-604 to relieve repression of HOXA9, forming a circ_0052184/miR-604/HOXA9 axis; it is proposed as a potential therapeutic target/diagnostic biomarker for CRC. |
| Confidence score: |
0.7032 |