circRNA basic information
circBase ID: -
Name: hsa_circ_CDR1AS
Synonym: Cdr1as / ciRS-7
Host Gene: -
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

HCC tissues; adjacent non-tumor tissues
Cell lines:

Hep3B; HepG2; SMMC-7721; Bel7402; HL-7702
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: CCNE1, PIK3CD
Associated microRNA: miR-7
Biological function: Acts as an oncogene in HCC by promoting cell proliferation and invasion.
Molecular mechanism: Targets miR-7 and modulates miR-7 downstream targets CCNE1 and PIK3CD, affecting proliferation and invasion.
Biological pathway or process:

proliferation (promotes); invasion (promotes); ceRNA regulation (other)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Transwell Assay; Western Blot
Clinical significance:

-
Description:

Cdr1as is up-regulated in HCC tissues and HCC cell lines. Functionally, Cdr1as promotes HCC cell proliferation and invasion, at least partly by targeting miR-7 and affecting miR-7 downstream targets (e.g., CCNE1 and PIK3CD).
Confidence score:

0.5358
Other information
Title:

The Circular RNA Cdr1as Act as an Oncogene in Hepatocellular Carcinoma through Targeting miR-7 Expression.

Journal: PloS one
Published: 2016
PubMed ID: 27391479
Study type:

combined biological and clinical study
Data availability: -
Code availability: -