| Expression pattern: |
UP |
| Associated gene: |
Ago2, MYC, TP53 |
| Associated microRNA: |
miR-1294 |
| Biological function: |
promotes proliferation, migration and invasion; inhibits apoptosis; enhances tamoxifen resistance (reduces tamoxifen sensitivity) in HR-positive breast cancer cells |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-1294 (Ago2-associated), modulating downstream targets such as MYC and TP53 and affecting tumor behaviors and tamoxifen response |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); drug resistance (promotes); ceRNA regulation (promotes); Wnt/beta-catenin (other); Hippo/YAP (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Transwell Assay; Annexin V/PI Flow Cytometry; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High hsa-circVIM expression is associated with shorter overall survival and may be an independent prognostic marker in breast cancer. |
| Description: |
hsa-circVIM is up-regulated in breast cancer (especially HR-positive and tamoxifen-resistant cells) and is associated with poorer overall survival. Functionally, hsa-circVIM promotes malignant phenotypes and tamoxifen resistance by sponging miR-1294 (Ago2-associated), with downstream implications for targets such as MYC and TP53 and pathways including Wnt and Hippo from enrichment analyses. |
| Confidence score: |
0.7507 |