circRNA basic information
circBase ID: -
Name: hsa_circ_FBXL4
Synonym: circRNA-FBXL4
Host Gene: FBXL4
Genomic location(hg19): chr6:99347144-99382755:.
Genomic location(hg38): chr6:98899268-98934879:.
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005115
MONDO name: temporal lobe epilepsy
Disease details: mesial temporal lobe epilepsy
Disease DO ID:
 3328
Disease MeSH ID:
 D004833
Disease NCIt ID:
 C177244
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

hippocampus
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: FBXL4
Associated microRNA: hsa-miR-378
Biological function: unspecific network effects due to large pool of mRNA targets
Molecular mechanism: circRNA-miRNA-mRNA network analysis; miRNA sponge/ceRNA-like mechanism inferred from miRNA binding sites and DE of target transcripts
Biological pathway or process:

ceRNA regulation (other); other pathway/process (other)
Detected method:
S
Validation methods:

RNA-seq; Bioinformatics Analysis
Clinical significance:

-
Description:

circRNA-FBXL4 is up-regulated in MTLE hippocampus and is analyzed as a miRNA sponge with many predicted/CLIP-supported miRNA binding sites (including hsa-miR-378 family), associated with broad downstream mRNA target dysregulation and enriched processes related to protein localization/modification.
Confidence score:

0.1768
Other information
Title:

Identification of Specific Circular RNA Expression Patterns and MicroRNA Interaction Networks in Mesial Temporal Lobe Epilepsy.

Journal: Frontiers in genetics
Published: 2020
PubMed ID: 33101384
Study type:

bioinformatics study
Data availability: EGAS00001003922
Code availability: -