circRNA basic information
circBase ID: -
Name: hsa_circ_HECW2
Synonym: hsa_circ_406010
Host Gene: HECW2
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0008903
MONDO name: lung cancer
Disease details: lung cancer
Disease DO ID:
 1324
Disease MeSH ID:
 -
Disease NCIt ID:
 C7377
Disease ICD11 ID:
 -
Disease OMIM ID:
 211980
Species: Human
Species details: Homo sapiens
Tissue specimen:

lung cancer tissues; paired adjacent normal lung tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: HECW2
Associated microRNA: hsa‐miR‐4778‐5p, hsa‐miR‐5690, hsa‐miR‐1200, hsa‐miR‐619‐5p, hsa‐miR‐212‐5p
Biological function: Associated with prognosis; low expression indicates poor prognosis in LCXW.
Molecular mechanism: May function via absorbing predicted miRNAs (miRNA sponge); investigated host gene HECW2 with no expression correlation.
Biological pathway or process:

ceRNA regulation (other); other pathway/process (other)
Detected method:
Q
M
Validation methods:

Microarray; RNase R Treatment; RT-qPCR; Sanger Sequencing; Clinical Sample Validation; Survival Analysis
Clinical significance:

Related to prognosis of LCXW patients; may serve as a novel potential biomarker for LCXW and for evaluating prognosis.
Description:

hsa_circRNA_406010 is significantly down-regulated in LCXW tumor tissues and lower expression is associated with poor prognosis. It is an intronic circRNA linked to host gene HECW2 (no expression correlation observed) and is predicted to sponge several miRNAs, supporting its potential as a prognostic biomarker.
Confidence score:

0.63
Other information
Title:

Analysis of circular RNA expression profiles of lung cancer in Xuanwei, China.

Journal: Journal of clinical laboratory analysis
Published: 2020
PubMed ID: 32844469
Study type:

combined biological and clinical study
Data availability: -
Code availability: -