circRNA basic information
circBase ID: hsa_circ_0067531
Name: hsa_circ_PIK3CB
Synonym: -
Host Gene: PIK3CB
Genomic location(hg19): chr3:138413627-138417937:-
Genomic location(hg38): chr3:138694785-138699095:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

HCC tumor tissues; adjacent normal tissues
Cell lines:

SK-Hep-1; LM3; Huh7; MHCC 97L
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: PI3K-AKT pathway
Associated microRNA: -
Biological function: May be involved in the development of HCC (associated with CD90-related phenotypes) via the PI3K pathway.
Molecular mechanism: Associated with PI3K signaling; detailed mechanism not functionally verified.
Biological pathway or process:

PI3K/AKT (other)
Detected method:
Q
M
Validation methods:

Microarray; RNase R Treatment; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RT-qPCR; Clinical Sample Validation
Clinical significance:

hsa_circ_0067531 may be a promising target/candidate to aid in the diagnosis and therapy of HCC.
Description:

hsa_circ_0067531 is down-regulated in HCC tissues versus adjacent normal tissues and is implicated (but not functionally verified) in CD90-related malignant phenotypes potentially via the PI3K/AKT pathway, suggesting diagnostic/therapeutic relevance.
Confidence score:

0.5909
Other information
Title:

CD90 promotes cell migration, viability and sphere‑forming ability of hepatocellular carcinoma cells.

Journal: International journal of molecular medicine
Published: 2018
PubMed ID: 29251325
Study type:

combined biological and clinical study
Data availability: -
Code availability: -