circRNA basic information
circBase ID: hsa_circ_0004913
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr17:62248459-62265775:-
Genomic location(hg38): chr17:64171099-64188415:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissue; non-tumor tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: PRC1
Associated microRNA: hsa-miR-182-5p
Biological function: may promote the progression of HCC by modulating macrophage infiltration (hypothesized)
Molecular mechanism: ceRNA/miRNA sponge (hypothesized)
Biological pathway or process:

immune regulation (other); ceRNA regulation (other)
Detected method:
M
Validation methods:

Microarray; Bioinformatics Analysis
Clinical significance:

-
Description:

This study identified hsa_circ_0004913 as a downregulated DEcircRNA in HCC and placed it in the PRC1-centered circRNA-miRNA-mRNA network. The authors propose (without experimental validation) that hsa_circ_0004913 may sponge hsa-miR-182-5p to relieve inhibition of PRC1, potentially altering macrophage infiltration and promoting HCC progression.
Confidence score:

0.1768
Other information
Title:

Construction of a circRNA-miRNA-mRNA Network Related to Macrophage Infiltration in Hepatocellular Carcinoma.

Journal: Frontiers in genetics
Published: 2020
PubMed ID: 33101367
Study type:

bioinformatics study
Data availability: TCGA; GSE14520; GSE94508; GSE97332; GSE78520
Code availability: -