| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
Potential biomarker for IPF-related diseases; detected and bioimaged in living pulmonary fibrosis cells under TGF-beta1 treatment. |
| Molecular mechanism: |
The study used a sequence-specific back-splice junction of circHIPK3 to activate a catalytic hairpin assembly reaction on a DNA octahedral amplifier, generating FRET signals for endogenous circHIPK3 detection; no disease-driving molecular mechanism was experimentally defined. |
| Biological pathway or process: |
fibrosis (other); other pathway/process (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Transfection |
| Clinical significance: |
circHIPK3 is proposed as a potential biomarker for specific IPF-related diseases and early diagnosis of IPF-related disease. |
| Description: |
This study used circHIPK3 as an IPF-related target circRNA and developed a DOA nanoprobe for in situ FRET detection and live-cell bioimaging. circHIPK3 was significantly upregulated in TGF-beta1-treated A549 pulmonary fibrosis cell models, supporting its potential as a biomarker for IPF-related diseases. |
| Confidence score: |
0.2586 |