circRNA basic information
circBase ID: hsa_circ_0122396
Name: hsa_circ_MED12L
Synonym: chr3:150903117-150911453+
Host Gene: MED12L
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004847
MONDO name: senile cataract
Disease details: age-related cataract
Disease DO ID:
 9669
Disease MeSH ID:
 -
Disease NCIt ID:
 C35012
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

anterior lens capsules
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: miR-23b-3p
Biological function: unknown
Molecular mechanism: Potential interaction with miR-23b-3p (selected as candidate circRNA with miR-23b-3p response elements).
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Bioinformatics Analysis; Clinical Sample Validation
Clinical significance:

-
Description:

hsa_circ_0122396 (MED12L-derived) is identified as a significantly down-regulated candidate circRNA in ARC anterior lens capsules. It was selected due to predicted miR-23b-3p response elements and its differential expression was verified by qRT-PCR, indicating involvement in a candidate circRNA-miR-23b-3p network in ARC.
Confidence score:

0.4032
Other information
Title:

Profiling of circular RNAs in age-related cataract reveals circZNF292 as an antioxidant by sponging miR-23b-3p.

Journal: Aging
Published: 2020
PubMed ID: 32913142
Study type:

combined biological and clinical study
Data availability: -
Code availability: -