| Expression pattern: |
UP |
| Associated gene: |
ERO1A, ACACA |
| Associated microRNA: |
miR-582-5p |
| Biological function: |
promotes proliferation, invasion, migration and glycolysis; inhibits apoptosis |
| Molecular mechanism: |
circ-ACACA sponges miR-582-5p to upregulate ERO1A (ceRNA mechanism), thereby promoting cervical cancer cell malignant phenotypes and glycolysis |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); glycolysis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Transfection; MTT; Colony Formation Assay; TUNEL; Transwell Assay; Wound Healing Assay; Luciferase Reporter Assay; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
circ-ACACA may be a promising biomarker for CC diagnosis and treatment. |
| Description: |
circ-ACACA is upregulated in cervical cancer cell lines and mainly localized in the cytoplasm. It promotes proliferation, invasion, migration and glycolysis while inhibiting apoptosis, at least partly by sponging miR-582-5p to increase ERO1A expression. |
| Confidence score: |
0.6742 |