circRNA basic information
circBase ID: -
Name: hsa_circ_CDR1AS
Synonym: CircRNA CDR1as
Host Gene: CDR1AS
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005380
MONDO name: osteonecrosis
Disease details: non-traumatic osteonecrosis of femoral head
Disease DO ID:
 0080008, 10159
Disease MeSH ID:
 D010020
Disease NCIt ID:
 C34880; C35476
Disease ICD11 ID:
 536467755
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

plasma; necrotic tissue; adjacent non-necrotic tissue
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Associated with radiographic and symptomatic severity in non-traumatic ONFH; higher expression indicates more pain and worse function.
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; ROC Analysis
Clinical significance:

Plasma CircCDR1as may serve as a biomarker/marker for radiographic progression (ARCO stage) in non-traumatic ONFH; higher plasma and local expression correlates with more severe symptoms (higher VAS, lower HHS).
Description:

CircCDR1as is up-regulated in plasma of non-traumatic ONFH patients and in local necrotic femoral-head tissue versus adjacent non-necrotic tissue. Higher plasma/local levels correlate with worse radiographic stage (ARCO) and worse symptoms (higher VAS, lower HHS), and plasma CircCDR1as shows potential as a biomarker for radiographic progression.
Confidence score:

0.4187
Other information
Title:

Plasma and local expressions of CircRNA CDR1as are linked with disease severity in patients with non-traumatic osteonecrosis of femoral head.

Journal: Journal of orthopaedic surgery and research
Published: 2020
PubMed ID: 33298118
Study type:

clinical study
Data availability: The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
Code availability: -