| Expression pattern: |
UP |
| Associated gene: |
FGFR1 |
| Associated microRNA: |
miR-198 |
| Biological function: |
May serve as a diagnostic biomarker for PTC; serum levels decrease after systematic treatment and help discriminate PTC from healthy controls and thyroid nodules. |
| Molecular mechanism: |
Reported tumor-promoter role via miR-198/FGFR1 axis (cited in discussion); study primarily evaluates diagnostic value in serum. |
| Biological pathway or process: |
ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Cohort Study; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
Up-regulated in PTC serum and can discriminate PTC from healthy controls and thyroid nodules; included in a combined diagnostic index with AUC >0.80. |
| Description: |
Serum circRAPGEF5 is up-regulated in PTC versus healthy controls and thyroid nodules and decreases after treatment. It contributes to a two-circRNA panel that improves diagnostic discrimination of PTC and may help monitor disease dynamics. |
| Confidence score: |
0.5121 |