circRNA basic information
circBase ID: hsa_circ_0008310
Name: hsa_circ_CNTROB
Synonym: -
Host Gene: CNTROB
Genomic location(hg19): chr17:7849045-7849304:+
Genomic location(hg38): chr17:7945727-7945986:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005061
MONDO name: lung adenocarcinoma
Disease details: Lung Adenocarcinoma
Disease DO ID:
 3910
Disease MeSH ID:
 C538231
Disease NCIt ID:
 C3512
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

cancer tissue; adjacent normal tissues
Cell lines:

MDA-MB-231; HRT18
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: NUSAP1, NEK2, CENPI
Associated microRNA: miR-3174, miR-760
Biological function: promotes cancer cells proliferation, migration, and invasion
Molecular mechanism: predicted ceRNA regulation via miR-3174 (and miR-760) affecting downstream targets such as NUSAP1, NEK2, and CENPI
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Bioinformatics Analysis
Clinical significance:

-
Description:

In pan-cancer, hsa_circ_0008310 is up-regulated and shows pro-malignant effects: its knockdown suppresses proliferation, migration, and invasion in cancer cell lines. The study predicts it may participate in a ceRNA network involving miR-3174 (and possibly miR-760) and downstream targets such as NUSAP1/NEK2/CENPI.
Confidence score:

0.5008
Other information
Title:

Screening and bioinformatics analysis of a ceRNA network based on the circular RNAs, miRNAs, and mRNAs in pan-cancer.

Journal: Cancer medicine
Published: 2020
PubMed ID: 33094914
Study type:

combined biological and clinical study
Data availability: GSE79634; GSE83521; GSE90737; GSE93522; GSE97332; GSE101586; GSE126095; TCGA
Code availability: -