| Expression pattern: |
UP |
| Associated gene: |
HOXA1, AGO2 |
| Associated microRNA: |
miR-218 |
| Biological function: |
Promotes cervical cancer cell proliferation, colony formation, migration and invasion; knockdown suppresses these malignant features. |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-218 to upregulate HOXA1 expression (ceRNA mechanism). |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Cohort Study; Survival Analysis; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Western Blot |
| Clinical significance: |
Increased expression of circEIF4G2 was associated with poor prognosis in patients with CC. |
| Description: |
circEIF4G2 is up-regulated in cervical cancer tissues and cell lines and is associated with poor prognosis. Functionally, circEIF4G2 promotes proliferation, colony formation, migration and invasion. Mechanistically, it sponges miR-218 to increase HOXA1 expression, forming a circEIF4G2/miR-218/HOXA1 regulatory axis. |
| Confidence score: |
0.7789 |