| Expression pattern: |
UP |
| Associated gene: |
WTAP |
| Associated microRNA: |
miR-455-3p |
| Biological function: |
Promotes prostate cancer cell proliferation, migration, invasion, and tumor growth in vivo. |
| Molecular mechanism: |
circ_0082878 acts as a miR-455-3p sponge and upregulates WTAP through the circ_0082878/miR-455-3p/WTAP axis. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Microarray; Clinical Sample Validation; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; Transwell Assay; Western Blot; In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
The circ_0082878/miR-455-3p/WTAP axis can probably become a therapeutic target for PCa. |
| Description: |
circ_0082878 is up-regulated in prostate cancer tissues and cells and functions as an oncogenic circRNA. It promotes proliferation, migration, invasion, and xenograft tumor growth by sponging miR-455-3p and upregulating WTAP, suggesting the circ_0082878/miR-455-3p/WTAP axis as a potential therapeutic target. |
| Confidence score: |
0.7968 |