| Expression pattern: |
UP |
| Associated gene: |
THBS2, PCNA, Bax, E-cadherin |
| Associated microRNA: |
miR-584-5p |
| Biological function: |
Promotes NSCLC cell proliferation, migration, invasion, metastasis and xenograft tumor growth; inhibits apoptosis. |
| Molecular mechanism: |
circ_0079530 acts as a ceRNA sponge for miR-584-5p, relieving miR-584-5p-mediated suppression of THBS2 and promoting NSCLC malignant progression. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); apoptosis (inhibits); EMT (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; EdU Staining; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
Provides a possible circRNA-targeted therapy for NSCLC. |
| Description: |
circ_0079530 is up-regulated in NSCLC tissues and cell lines and acts as an oncogenic circRNA. It promotes proliferation, migration, invasion, metastasis and xenograft tumor growth while suppressing apoptosis, mainly by sponging miR-584-5p to increase THBS2 expression. The study suggests circ_0079530 as a potential circRNA-targeted therapeutic candidate for NSCLC. |
| Confidence score: |
0.8299 |