| Expression pattern: |
UP |
| Associated gene: |
GART |
| Associated microRNA: |
miR-873-3p |
| Biological function: |
Promotes gastric cancer cell proliferation, migration, invasion, and metastasis; knockdown decreases cell viability, migration, and invasion. |
| Molecular mechanism: |
circRNA_0043691 acts as a miR-873-3p sponge and positively regulates GART expression through the miR-873-3p-GART axis. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Transfection; CCK8; Transwell Assay; Luciferase Reporter Assay; Western Blot |
| Clinical significance: |
Knockdown of circRNA_0043691 could be a potential therapeutic target for GC. |
| Description: |
circRNA_0043691 is upregulated in gastric cancer tissues and functions as an oncogenic circRNA. It promotes GC cell proliferation, migration, invasion, and metastasis by sponging miR-873-3p and upregulating GART expression, and its knockdown is proposed as a potential therapeutic strategy. |
| Confidence score: |
0.6479 |