| Expression pattern: |
DN |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
Biomarker potential for HCM and indicator of disease severity in HOCM (negatively correlated with LVOT gradient and IVS thickness). |
| Molecular mechanism: |
Not specified (evaluated as circulating biomarker; mechanistic interactions not experimentally investigated). |
| Biological pathway or process: |
not specified |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
Circulating circTMEM56 can distinguish between healthy subjects and HCM/HNCM/HOCM patients (ROC AUC reported); additionally indicates disease severity in HOCM via negative correlation with echocardiographic parameters. |
| Description: |
Serum circTMEM56 is significantly down-regulated in HCM patients versus controls. It demonstrates diagnostic discrimination for HCM subtypes and correlates with echocardiographic severity measures in HOCM, suggesting utility as a circulating biomarker and severity indicator. |
| Confidence score: |
0.459 |