circRNA basic information
circBase ID: -
Name: hsa_circ_POLA2
Synonym: circ_POLA2
Host Gene: POLA2
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0011962
MONDO name: endometrial cancer
Disease details: endometrial cancer
Disease DO ID:
 1380
Disease MeSH ID:
 -
Disease NCIt ID:
 C27815
Disease ICD11 ID:
 -
Disease OMIM ID:
 608089
Species: Human
Species details: Homo sapiens
Tissue specimen:

EC tissue; paired adjacent normal tissues
Cell lines:

HEC-1-A; RL95-2
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: miR-31
Biological function: promotes endometrial cancer cell proliferation
Molecular mechanism: circ_POLA2 suppresses miR-31 expression via increasing miR-31 methylation
Biological pathway or process:

proliferation (promotes); other pathway/process (other)
Detected method:
Q
Validation methods:

RT-qPCR; MSP (Methylation-Specific PCR); Transfection; CCK8; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

-
Description:

circ_POLA2 is up-regulated in endometrial cancer tissues and promotes EC cell proliferation. Mechanistically, circ_POLA2 increases methylation of the miR-31 gene, reducing miR-31 expression and attenuating the anti-proliferative effect of miR-31 in EC cells.
Confidence score:

0.6102
Other information
Title:

circRNA circ_POLA2 increases microRNA-31 methylation to promote endometrial cancer cell proliferation.

Journal: Oncology letters
Published: 2021
PubMed ID: 34539866
Study type:

combined biological and clinical study
Data availability: The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
Code availability: -