| Expression pattern: |
UP |
| Associated gene: |
TGF-beta1 |
| Associated microRNA: |
miR-26a-5p |
| Biological function: |
promotes osteosarcoma cell proliferation, migration, invasion/metastasis and tumor growth (oncogenic role) |
| Molecular mechanism: |
ceRNA sponge of miR-26a-5p leading to increased TGF-beta1 expression |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); TGF-beta/SMAD (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Luciferase Reporter Assay; Transfection; MTT; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Western Blot; Clinical Sample Validation; Survival Analysis; In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
up-regulated in patient serum and tissues; high circ_0051079 levels associated with shorter overall survival; proposed as a potential diagnostic biomarker |
| Description: |
circ_0051079 is up-regulated in osteosarcoma tissues and patient serum and functions as an oncogenic circRNA. It promotes proliferation and metastasis-related behaviors by sponging miR-26a-5p, thereby relieving repression of TGF-beta1 and activating TGF-beta signaling. High circ_0051079 expression is associated with shorter overall survival and may serve as a diagnostic biomarker. |
| Confidence score: |
0.7373 |