circRNA basic information
circBase ID: hsa_circ_0004639
Name: hsa_circ_NECTIN3
Synonym: -
Host Gene: NECTIN3
Genomic location(hg19): chr3:110830876-110841085:+
Genomic location(hg38): chr3:111112029-111122238:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0015075
MONDO name: thyroid gland carcinoma
Disease details: Thyroid Carcinoma
Disease DO ID:
 3963
Disease MeSH ID:
 -
Disease NCIt ID:
 C4815
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

cancer tissue; adjacent normal tissues
Cell lines:

T47D; HRT18
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: NUSAP1, NEK2, CENPI
Associated microRNA: miR-507, miR-4517, miR-3174
Biological function: inhibits cancer cells’ proliferation, migration, and invasion
Molecular mechanism: predicted ceRNA regulation involving miR-3174 and downstream targets such as NUSAP1, NEK2, and CENPI; miR-507 and miR-4517 were also affected upon overexpression
Biological pathway or process:

proliferation (inhibits); migration (inhibits); invasion (inhibits); ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Bioinformatics Analysis
Clinical significance:

-
Description:

In pan-cancer, hsa_circ_0004639 is down-regulated and acts as a tumor-suppressive circRNA in functional assays: its overexpression inhibits proliferation, migration, and invasion. The study predicts it may be involved in a ceRNA network affecting miR-3174 (and also miR-507/miR-4517 responses) with potential downstream targets including NUSAP1/NEK2/CENPI.
Confidence score:

0.5008
Other information
Title:

Screening and bioinformatics analysis of a ceRNA network based on the circular RNAs, miRNAs, and mRNAs in pan-cancer.

Journal: Cancer medicine
Published: 2020
PubMed ID: 33094914
Study type:

combined biological and clinical study
Data availability: GSE79634; GSE83521; GSE90737; GSE93522; GSE97332; GSE101586; GSE126095; TCGA
Code availability: -