circRNA basic information
circBase ID: hsa_circ_0002908
Name: hsa_circ_PTK2
Synonym: -
Host Gene: PTK2
Genomic location(hg19): chr8:141840570-141874498:-
Genomic location(hg38): chr8:140830471-140864399:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0018076
MONDO name: tuberculosis
Disease details: tuberculosis
Disease DO ID:
 399
Disease MeSH ID:
 D014376
Disease NCIt ID:
 C3423
Disease ICD11 ID:
 2072728114
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

peripheral blood mononuclear cells (PBMCs)
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Potential diagnostic biomarker to differentiate active TB patients from healthy controls.
Molecular mechanism: Not specified; identified as part of a pathway-based PBMC circRNA signature for TB classification.
Biological pathway or process:

immune regulation (other)
Detected method:
Q
S
M
Validation methods:

RNA-seq; Microarray; RNase R Treatment; RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

Included in a PBMC 7-circRNA signature with diagnostic performance (AUC 0.946) differentiating TB patients from healthy controls.
Description:

hsa_circ_0002908 (host gene PTK2) is up-regulated in PBMCs from active pulmonary TB patients and is part of a 7-circRNA PBMC diagnostic signature validated in an independent cohort (AUC 0.946).
Confidence score:

0.6142
Other information
Title:

Potential Diagnostic Power of Blood Circular RNA Expression in Active Pulmonary Tuberculosis.

Journal: EBioMedicine
Published: 2018
PubMed ID: 29248507
Study type:

combined biological and clinical study
Data availability: SRP115429; GSE103188
Code availability: -