circRNA basic information
circBase ID: -
Name: hsa_circ_FAT1
Synonym: circFAT1(e2)
Host Gene: FAT1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

CRC tumor tissues; adjacent normal tissues
Cell lines:

HCT116; RKO; Caco-2; FHC; 293T
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: ITGA6
Associated microRNA: miR-30e-5p
Biological function: promotes CRC cell proliferation, migration and invasion
Molecular mechanism: Acts as a ceRNA/miRNA sponge for miR-30e-5p to increase ITGA6 expression.
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Transwell Assay; Luciferase Reporter Assay; Bioinformatics Analysis
Clinical significance:

-
Description:

circFAT1(e2) is up-regulated in colorectal cancer tissues/cell lines and functions as an oncogenic circRNA. It sponges miR-30e-5p to relieve repression of ITGA6, thereby promoting CRC cell proliferation, migration, and invasion in vitro.
Confidence score:

0.6369
Other information
Title:

Circular RNA circFAT1(e2) Promotes Colorectal Cancer Tumorigenesis via the miR-30e-5p/ITGA6 Axis.

Journal: Computational and mathematical methods in medicine
Published: 2021
PubMed ID: 34257702
Study type:

combined biological and clinical study
Data availability: The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
Code availability: -