| Expression pattern: |
UP |
| Associated gene: |
CDK6 |
| Associated microRNA: |
miR-520 h |
| Biological function: |
Facilitates medulloblastoma progression; promotes Daoy cell viability, migration, invasion, and cell cycle progression. |
| Molecular mechanism: |
circSKA3 acts as a competing endogenous RNA by sponging miR-520 h to enhance CDK6 expression. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); cell cycle (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Transwell Assay; Cell Cycle Assay; Luciferase Reporter Assay; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
The circSKA3/miR-520 h/CDK6 pathway has potential as a therapeutic target for medulloblastoma treatment. |
| Description: |
circSKA3 is up-regulated in medulloblastoma tissues and functions as an oncogenic circRNA. It promotes medulloblastoma cell proliferation, migration, invasion, and cell cycle progression by sponging miR-520 h and regulating CDK6 expression, suggesting the circSKA3/miR-520 h/CDK6 axis as a potential therapeutic target. |
| Confidence score: |
0.6521 |