circRNA basic information
circBase ID: -
Name: hsa_circ_MFN2
Synonym: hsa_circRNA_100053
Host Gene: MFN2
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004981
MONDO name: atrial fibrillation
Disease details: atrial fibrillation
Disease DO ID:
 0060224
Disease MeSH ID:
 D001281
Disease NCIt ID:
 C50466
Disease ICD11 ID:
 171698302
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

heart tissue; blood
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: TRPV1
Associated microRNA: hsa-miR-455-5p
Biological function: May be involved in the process of AF; implicated in heart protection (via miR-455-5p/TRPV1).
Molecular mechanism: ceRNA regulatory interaction involving hsa-miR-455-5p and TRPV1.
Biological pathway or process:

ceRNA regulation (other)
Detected method:
M
Validation methods:

Bioinformatics Analysis; Microarray
Clinical significance:

-
Description:

hsa_circRNA_100053 (host gene MFN2) is down-regulated in AF heart tissue and was proposed to participate in AF through a ceRNA relationship with hsa-miR-455-5p affecting TRPV1 expression, potentially linking to cardioprotective responses.
Confidence score:

0.1768
Other information
Title:

Identification of Circular RNA-MicroRNA-Messenger RNA Regulatory Network in Atrial Fibrillation by Integrated Analysis.

Journal: BioMed research international
Published: 2020
PubMed ID: 33062700
Study type:

combined biological and clinical study
Data availability: GSE129409; GSE68475; GSE70887; GSE31821; GSE135445
Code availability: -