| Expression pattern: |
UP |
| Associated gene: |
ADAM10 |
| Associated microRNA: |
miR-212-3p |
| Biological function: |
Enhances NSCLC malignant progression by promoting cell viability, migration, invasion, glycolysis, and tumor growth. |
| Molecular mechanism: |
circNFIX acts as a miR-212-3p sponge to up-regulate ADAM10 (ceRNA mechanism). |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); glycolysis (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Survival Analysis; Transfection; CCK8; Transwell Assay; Luciferase Reporter Assay; RNA Pull-Down; Western Blot; In Vivo Animal Model |
| Clinical significance: |
circNFIX was overexpressed in NSCLC and predicted poor prognosis of NSCLC patients. |
| Description: |
circNFIX is up-regulated in NSCLC tissues/cells and high circNFIX is associated with worse overall survival. Functionally, circNFIX promotes NSCLC proliferation/viability, migration, invasion, glycolysis and in vivo tumor growth by sponging miR-212-3p to de-repress ADAM10. |
| Confidence score: |
0.7353 |