| Expression pattern: |
UP |
| Associated gene: |
E2F5, Ago2, p53, PUMA, P21 |
| Associated microRNA: |
miR-212-3p |
| Biological function: |
promotes proliferation; promotes tumor growth in vivo |
| Molecular mechanism: |
Acts as a ceRNA/molecular sponge for miR-212-3p to upregulate E2F5; inhibits p53 signaling pathway |
| Biological pathway or process: |
proliferation (promotes); p53 signaling (inhibits); ceRNA regulation (promotes); ERK (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; FISH / smFISH; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Western Blot; In Vivo Animal Model; Bioinformatics Analysis; Clinical Sample Validation |
| Clinical significance: |
circFAM13B may represent used as a novel biomarker and target for the diagnosis and clinical treatment of HCC. |
| Description: |
circFAM13B is up-regulated in HCC tissues/cell lines and promotes HCC cell proliferation and xenograft tumor growth. Mechanistically, it functions as a ceRNA by sponging miR-212-3p to relieve repression of E2F5, thereby suppressing p53 pathway activity (and is also discussed as activating ERK signaling). |
| Confidence score: |
0.8375 |