circRNA basic information
circBase ID: -
Name: hsa_circ_FAT1
Synonym: circFAT1
Host Gene: -
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005105
MONDO name: melanoma
Disease details: melanoma
Disease DO ID:
 1909
Disease MeSH ID:
 D008545
Disease NCIt ID:
 C3224
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

malignant melanoma tissues; melanocytic nevi tissues
Cell lines:

SK-Mel-28; A375; SK-MEL-28; HEK-293 T
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: SLC7A11
Associated microRNA: miR-375
Biological function: Promotes proliferation, migration, invasion and clone formation of malignant melanoma cells.
Molecular mechanism: circFAT1 acts as a miRNA sponge for miR-375 and positively regulates SLC7A11 expression.
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Sanger Sequencing; Clinical Sample Validation; circRIP; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Bioinformatics Analysis
Clinical significance:

CircFAT1 may be a promising target for the treatment of malignant melanoma.
Description:

circFAT1 is up-regulated in malignant melanoma tissues and promotes melanoma cell proliferation, migration, invasion and clone formation. Mechanistically, it functions as a sponge for miR-375, thereby increasing SLC7A11 expression, and may represent a therapeutic target for malignant melanoma.
Confidence score:

0.7551
Other information
Title:

CircFAT1 Promotes the Proliferation and Invasion of Malignant Melanoma through miR375-SLC7A11 Signal Axis.

Journal: Anti-cancer agents in medicinal chemistry
Published: 2023
PubMed ID: 37303180
Study type:

combined biological and clinical study
Data availability: The data and supportive information is available within the article.
Code availability: -