| Expression pattern: |
UP |
| Associated gene: |
CDK7 |
| Associated microRNA: |
miR-33a-5p |
| Biological function: |
Promotes proliferation, migration and invasion and inhibits apoptosis in gastric cancer; attenuates GA-induced anti-tumor effects. |
| Molecular mechanism: |
Acts as a ceRNA (miRNA sponge) for miR-33a-5p to upregulate CDK7. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Transfection; Luciferase Reporter Assay; MTT; Colony Formation Assay; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; Bioinformatics Analysis; Clinical Sample Validation; In Vivo Animal Model |
| Clinical significance: |
- |
| Description: |
circ_ASAP2 is up-regulated in gastric cancer tissues and cells. It promotes GC cell proliferation, migration and invasion and inhibits apoptosis by sponging miR-33a-5p to upregulate CDK7, thereby weakening the anti-tumor effects of gambogic acid. |
| Confidence score: |
0.7595 |