| Expression pattern: |
UP |
| Associated gene: |
HOXC8, Ago2 |
| Associated microRNA: |
miR-211-5p |
| Biological function: |
promotes paclitaxel resistance, proliferation, migration and invasion; inhibits apoptosis in ovarian cancer cells |
| Molecular mechanism: |
ceRNA mechanism: circNRIP1 sponges miR-211-5p to upregulate HOXC8, thereby enhancing paclitaxel resistance |
| Biological pathway or process: |
chemoresistance (promotes); proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; MTT; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; In Vivo Animal Model; Clinical Sample Validation |
| Clinical significance: |
circNRIP1 might be a potential target for OC resistance treatment |
| Description: |
circNRIP1 is up-regulated in paclitaxel-resistant ovarian cancer tissues and cells. circNRIP1 promotes paclitaxel resistance and malignant phenotypes by acting as a cytoplasmic ceRNA that sponges miR-211-5p, thereby increasing HOXC8 expression; circNRIP1 knockdown sensitizes tumors to paclitaxel in a xenograft model. |
| Confidence score: |
0.7983 |