| Expression pattern: |
UP |
| Associated gene: |
COL1A1 |
| Associated microRNA: |
hsa-miR-328-3p |
| Biological function: |
promotes breast cancer cell proliferation, energy metabolism and angiogenesis; promotes tumor growth and inflammation in vivo |
| Molecular mechanism: |
acts as a miR-328-3p sponge to relieve miR-328-3p-mediated repression of COL1A1 |
| Biological pathway or process: |
proliferation (promotes); angiogenesis (promotes); ceRNA regulation (promotes); inflammation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; FISH / smFISH; RNA Pull-Down; Luciferase Reporter Assay; Bioinformatics Analysis; Transfection; CCK8; Western Blot; Tube Formation Assay; IHC (Immunohistochemistry); ELISA; In Vivo Animal Model; Survival Analysis; Clinical Sample Validation |
| Clinical significance: |
High hsa_circRNA_002178 expression is associated with worse prognosis in breast cancer patients |
| Description: |
In breast cancer, hsa_circRNA_002178 is up-regulated and mainly localized in the cytoplasm. It promotes malignant phenotypes (proliferation, energy metabolism and angiogenesis) and tumor growth/inflammation by sponging miR-328-3p, thereby relieving miR-328-3p-mediated repression of COL1A1. |
| Confidence score: |
0.8066 |