| Expression pattern: |
UP |
| Associated gene: |
PEAK1 |
| Associated microRNA: |
miR-145-5p |
| Biological function: |
May contribute to CRC pathogenesis and act as a biomarker; proposed to regulate PEAK1 via sponging miR-145-5p. |
| Molecular mechanism: |
Putative ceRNA mechanism: circ0009910 sponges miR-145-5p to regulate PEAK1 expression. |
| Biological pathway or process: |
ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
ROC curve analysis showed circ0009910 level as a discriminative biomarker for CRC (AUC = 0.82; 72% sensitivity and 84% specificity). |
| Description: |
circ0009910 is upregulated in colorectal cancer tissues and is proposed to act as a ceRNA that sponges miR-145-5p, thereby associating with increased PEAK1 expression. Its expression shows diagnostic potential for CRC based on ROC analysis. |
| Confidence score: |
0.6556 |