| Expression pattern: |
UP |
| Associated gene: |
MEMO1, Ago2 |
| Associated microRNA: |
miR-485-3p, miR-543, miR-337-3p |
| Biological function: |
promotes CRC cell proliferation, migration, invasion, EMT, tumor growth and metastatic progression; inhibits apoptosis |
| Molecular mechanism: |
ceRNA mechanism: circ-MEMO1 sponges miR-485-3p/miR-543/miR-337-3p to elevate MEMO1 expression |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); EMT (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; FISH / smFISH; IF (Immunofluorescence); Clinical Sample Validation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; Colony Formation Assay; Transwell Assay; TUNEL; In Vivo Animal Model; H&E Staining; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
circ-MEMO1 might be a promising therapeutic target for CRC |
| Description: |
hsa_circ_0007385/circ-MEMO1 is up-regulated in colorectal cancer tissues and cell lines. It acts as an oncogenic circRNA that promotes proliferation, migration, invasion, EMT, tumor growth and metastatic progression while suppressing apoptosis. Mechanistically, it functions as a ceRNA for miR-485-3p, miR-543 and miR-337-3p to positively regulate MEMO1 expression, making it a potential therapeutic target for CRC. |
| Confidence score: |
0.78 |