| Expression pattern: |
UP |
| Associated gene: |
PTEN |
| Associated microRNA: |
- |
| Biological function: |
promotes NSCLC cell proliferation by reducing the accumulation of PTEN protein |
| Molecular mechanism: |
circENTPD7 decreases PTEN protein without changing PTEN mRNA, suggesting regulation at translation or protein degradation level |
| Biological pathway or process: |
proliferation (promotes); PI3K/AKT (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Cohort Study; Survival Analysis; Transfection; Western Blot; ELISA; CCK8 |
| Clinical significance: |
high expression levels of circENTPD7 predicts poor survival of NSCLC patients |
| Description: |
circENTPD7 is up-regulated in NSCLC tissues and its high expression is associated with poorer overall survival. Functionally, circENTPD7 promotes NSCLC cell proliferation by reducing PTEN protein accumulation without changing PTEN mRNA, suggesting translational or post-translational regulation of PTEN. |
| Confidence score: |
0.6527 |