circRNA basic information
circBase ID: hsa_circ_0079875
Name: hsa_circ_ANLN
Synonym: hsa_-circ_0079875
Host Gene: ANLN
Genomic location(hg19): chr7:36450122-36450775:+
Genomic location(hg38): chr7:36410513-36411166:+
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

HCC tissues; tumor-adjacent tissues; cancer and tumor-adjacent tissues; tumor tissue
Cell lines:

Li-7; SK-HEP-1; PLC/PRF/5; HuH-7
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: NRAS, TNFRSF13C
Associated microRNA: miR-665, miR-519d-5p, miR-874-3p, miR-576-3p, miR-938
Biological function: Promotes HCC cell proliferation, migration, invasion, S-phase cell cycle progression, and tumor growth; inhibits apoptosis; associated with larger tumor tissue, microvascular invasion, higher AFP levels, and poor prognosis.
Molecular mechanism: hsa_circ_0079875 functions as a competitive endogenous RNA and may sponge miR-519d-5p to regulate NRAS expression.
Biological pathway or process:

ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); cell cycle (promotes)
Detected method:
Q
H
S
Validation methods:

Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; circRNA-seq; RT-qPCR; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Transwell Assay; Wound Healing Assay; RIP (RNA Immunoprecipitation); RNA-seq; IHC (Immunohistochemistry); TUNEL; H&E Staining; In Vivo Animal Model; Survival Analysis; Bioinformatics Analysis
Clinical significance:

High expression is associated with larger tumor diameter, microvascular invasion, higher AFP levels, and poorer prognosis; hsa_circ_0079875 may be a potential prognostic marker and therapeutic target for HCC.
Description:

hsa_circ_0079875 is an ANLN-derived circRNA up-regulated in HCC tissues and mainly localized in the cytoplasm. It promotes HCC progression by enhancing proliferation, migration, invasion, S-phase cell-cycle progression, and tumor growth while inhibiting apoptosis, likely through a ceRNA mechanism involving miR-519d-5p and NRAS. High hsa_circ_0079875 expression is associated with aggressive clinicopathological features and poor survival, suggesting prognostic and therapeutic potential.
Confidence score:

0.8585
Other information
Title:

Hsa_circ_0079875 functions as a competitive endogenous RNA to promote hepatocellular carcinoma progression.

Journal: Cell cycle (Georgetown, Tex.)
Published: 2024
PubMed ID: 38684479
Study type:

combined biological and clinical study
Data availability: GTRD(http://gtrd20-06.biouml.org); Human TFDB (http://bioinfo.life.hust.edu.cn/HumanTFDB#!/); JASPAR(https://jaspar.genereg.net); UALCAN (http://ualcan.path.uab.edu/); CircInteracome (https://circinteractome.nia.nih.gov/); dbDEMC (https://www.biosino.org/dbDEMC/index); GEPIA (http://gepia.cancer-pku.cn/detail.php/); KMplot (http://kmplot.com/analysis/); TargetScan (https:// www.targetscan.org/vert_80/); StarBase(https://star base.sysu.edu.cn/); miRDB(http://mirdb.org/)
Code availability: -