| Expression pattern: |
UP |
| Associated gene: |
FOXP1 |
| Associated microRNA: |
miR-338-3p |
| Biological function: |
Promotes HCC progression by increasing cell viability, proliferation, migration, and invasion, and decreasing apoptosis; promotes EMT-like changes (decreases E-cadherin and increases N-cadherin) and supports tumor growth and metastasis in vivo. |
| Molecular mechanism: |
Acts as a ceRNA by sponging miR-338-3p, thereby relieving miR-338-3p-mediated repression of FOXP1 and promoting malignant phenotypes in HCC. |
| Biological pathway or process: |
apoptosis (inhibits); proliferation (promotes); migration (promotes); invasion (promotes); EMT (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; FISH / smFISH; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Annexin V/PI Flow Cytometry; Wound Healing Assay; Transwell Assay; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; H&E Staining; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High expression of hsa_circ_104566 in HCC tissues is significantly associated with poor prognosis/shorter survival and correlates with aggressive clinicopathological features (tumor size, TNM stage, lymph node involvement). |
| Description: |
hsa_circ_104566 is up-regulated in HCC and its high expression is associated with shorter overall survival. Functionally, it promotes proliferation, migration, invasion and EMT-like changes and inhibits apoptosis by acting as a ceRNA that sponges miR-338-3p to increase FOXP1, and its knockdown suppresses tumor growth and metastasis in xenograft models. |
| Confidence score: |
0.8156 |