circRNA basic information
circBase ID: -
Name: hsa_circ_HIPK3
Synonym: circHIPK3
Host Gene: HIPK3
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small-cell lung cancer
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

NSCLC tissue
Cell lines:

H1299; A549; BEAS-2B; H1975
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: BDNF
Associated microRNA: miR-107
Biological function: Promotes NSCLC cell proliferation, migration, and invasion (tumor progression).
Molecular mechanism: Acts as a miR-107 sponge (ceRNA), relieving miR-107 repression of BDNF.
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Transwell Assay
Clinical significance:

Potential biomarker/marker for NSCLC screening and treatment.
Description:

circHIPK3 is up-regulated in NSCLC cells and promotes proliferation, migration, and invasion. Mechanistically, it sponges miR-107 to relieve repression of the downstream target BDNF, forming a circHIPK3/miR-107/BDNF ceRNA axis with potential biomarker relevance in NSCLC.
Confidence score:

0.5416
Other information
Title:

circHIPK3 Acts as Competing Endogenous RNA and Promotes Non-Small-Cell Lung Cancer Progression through the miR-107/BDNF Signaling Pathway.

Journal: BioMed research international
Published: 2020
PubMed ID: 33015172
Study type:

biological research
Data availability: The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
Code availability: -