| Expression pattern: |
DN |
| Associated gene: |
SATB2, CRMP1, CXCR4 |
| Associated microRNA: |
miR-6717-5p |
| Biological function: |
hsa_circ_0051488 functions as a tumor-suppressive circRNA in LUSC; its low expression is associated with more serious pathology, while overexpression reduces tumor cell proliferation, colony formation, migration, and invasion. |
| Molecular mechanism: |
hsa_circ_0051488 acts as a cytoplasmic competing endogenous RNA sponge for miR-6717-5p, thereby modulating SATB2 expression; SATB2 is linked to inhibition of tumor-related pathways and positive correlation with CRMP1. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (inhibits); migration (inhibits); invasion (inhibits); NF-kappaB (inhibits); oxidative phosphorylation (inhibits); other pathway/process (inhibits) |
| Detected method: |
Q
M
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; MTT; Colony Formation Assay; Transwell Assay; Western Blot; In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
Low hsa_circ_0051488 expression in cancer tissues is inversely correlated with tumor diameter, lymphatic metastasis, and TNM stage; low expression is related to more serious pathology. |
| Description: |
hsa_circ_0051488 is an ERCC1-derived circRNA that is down-regulated in LUSC tissues and during BPDE-induced malignant transformation. It mainly localizes in the cytoplasm and suppresses LUSC-related malignant phenotypes by acting as a ceRNA sponge for miR-6717-5p, thereby regulating SATB2. Clinically, low hsa_circ_0051488 expression is associated with larger tumor diameter, lymphatic metastasis, and advanced TNM stage. |
| Confidence score: |
0.7799 |