circRNA basic information
circBase ID: -
Name: hsa_circ_HIPK3
Synonym: circHIPK3
Host Gene: HIPK3
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0021042
MONDO name: glioma
Disease details: glioma
Disease DO ID:
 -
Disease MeSH ID:
 D005910
Disease NCIt ID:
 C3059
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

glioma tissues; normal tissues
Cell lines:

SW1783; U373
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: CCND2, AGO1, AGO2, AGO3, CAPRIN1, EIF4A3, ELAVL1, FMR1, FUS, FXR1, FXR2, IGF2BP1, IGF2BP2, IGF2BP3, LIN28A, LIN28B, MOV10, PTBP1, U2AF2, UPF1
Associated microRNA: miR-124
Biological function: Promotes proliferation, migration and invasion of glioma cells.
Molecular mechanism: Acts as a miRNA sponge for miR-124 to increase CCND2 expression (ceRNA mechanism).
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Transfection; CCK8; Transwell Assay; Luciferase Reporter Assay; Bioinformatics Analysis
Clinical significance:

-
Description:

circHIPK3 is up-regulated in glioma tissues/cell lines and promotes glioma cell proliferation, migration, and invasion. Mechanistically, it acts as a ceRNA by sponging miR-124, thereby elevating CCND2 expression.
Confidence score:

0.5416
Other information
Title:

Circular RNA CircHIPK3 Elevates CCND2 Expression and Promotes Cell Proliferation and Invasion Through miR-124 in Glioma.

Journal: Frontiers in genetics
Published: 2020
PubMed ID: 33005182
Study type:

combined biological and clinical study
Data availability: -
Code availability: -