| Expression pattern: |
UP |
| Associated gene: |
FGFR1, Ago2 |
| Associated microRNA: |
miR‐326 |
| Biological function: |
Promotes breast cancer cell proliferation, colony formation, cell cycle progression, migration, invasion and tumor growth; inhibits apoptosis. |
| Molecular mechanism: |
Acts as a ceRNA/miRNA sponge for miR-326 to upregulate FGFR1 expression. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); cell cycle (promotes); migration (promotes); invasion (promotes); metastasis (other); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Colony Formation Assay; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; In Vivo Animal Model; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
circ_0000518 might be a promising target for BC treatment. |
| Description: |
circ_0000518 is up-regulated in breast cancer tissues and cells and promotes malignant phenotypes (proliferation, colony formation, cell-cycle progression, migration/invasion) while inhibiting apoptosis. Mechanistically, it functions as a ceRNA that sponges miR-326 to increase FGFR1 expression, thereby promoting tumor growth in a cell line-derived xenograft model. |
| Confidence score: |
0.7302 |