| Expression pattern: |
UP |
| Associated gene: |
TMPRSS4 |
| Associated microRNA: |
miR-936 |
| Biological function: |
Circ_0076305 contributes to paclitaxel resistance, proliferation, migration, invasion, and glycolysis, and suppresses apoptosis in NSCLC cells; circ_0076305 knockdown increases PTX sensitivity and exerts anti-tumor effects. |
| Molecular mechanism: |
Circ_0076305 acts as a ceRNA/miRNA sponge for miR-936, thereby up-regulating TMPRSS4 expression and promoting paclitaxel resistance and malignant phenotypes in NSCLC cells. |
| Biological pathway or process: |
chemoresistance (promotes); drug resistance (promotes); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); glycolysis (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Western Blot; Bioinformatics Analysis; Luciferase Reporter Assay; RNA Pull-Down; Transfection; CCK8; EdU Staining; Transwell Assay; Annexin V/PI Flow Cytometry; Clinical Sample Validation; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
Circ_0076305 knockdown may provide a new strategy to overcome the PTX resistance of NSCLC patients. |
| Description: |
Circ_0076305 is up-regulated in paclitaxel-resistant NSCLC tissues and cells. It promotes PTX resistance and malignant cellular behaviors by sponging miR-936 to increase TMPRSS4 expression, while its knockdown enhances PTX sensitivity, suppresses proliferation, migration, invasion and glycolysis, and promotes apoptosis. |
| Confidence score: |
0.7552 |