| Expression pattern: |
UP |
| Associated gene: |
MYO6, Ago2 |
| Associated microRNA: |
miR-502-5p |
| Biological function: |
Promotes CRC cell glycolysis, proliferation, migration and invasion; inhibits apoptosis; promotes tumor growth in vivo. |
| Molecular mechanism: |
Acts as a ceRNA sponge for miR-502-5p, thereby relieving miR-502-5p-mediated repression of MYO6 and promoting CRC progression and glycolysis. |
| Biological pathway or process: |
glycolysis (promotes); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Wound Healing Assay; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; Western Blot; Clinical Sample Validation; Survival Analysis; In Vivo Animal Model |
| Clinical significance: |
High hsa_circ_0000231 expression was related to low survival rate in CRC patients. |
| Description: |
hsa_circ_0000231 is up-regulated in colorectal cancer and its high expression is associated with poorer survival. It promotes CRC cell proliferation, migration/invasion and glycolysis and inhibits apoptosis by sponging miR-502-5p to upregulate MYO6; knockdown suppresses tumor growth in a xenograft model. |
| Confidence score: |
0.7857 |