| Expression pattern: |
UP |
| Associated gene: |
TP53, MYC, AKT1 |
| Associated microRNA: |
- |
| Biological function: |
associated with hepatocarcinogenesis and progression; carcinogenic role; prognostic biomarker potential |
| Molecular mechanism: |
predicted ceRNA/miRNA sponge network affecting target genes and pathways (in silico) |
| Biological pathway or process: |
MAPK (other); Ras (other); ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; Bioinformatics Analysis; RT-qPCR; Sanger Sequencing; divergent primers PCR; Back-Splice Junction PCR / divergent primers PCR; Clinical Sample Validation; Survival Analysis; ROC Analysis; Cohort Study |
| Clinical significance: |
high hsa_circ_0000517 expression was associated with adverse prognosis in HCC patients; higher expression was related to worse TNM stage; nomogram built on AFP and has_circ_0000517 showed prognostic value |
| Description: |
hsa_circ_0000517 is up-regulated in HCC tumor tissues and its high expression is associated with worse OS/DFS and higher TNM stage. Bioinformatics analyses predict it acts as a miRNA sponge, influencing targets such as TP53, MYC and AKT1 and enriching MAPK/Ras-related pathways, supporting its potential as a prognostic biomarker. |
| Confidence score: |
0.7278 |