| Expression pattern: |
DN |
| Associated gene: |
SOCS3 |
| Associated microRNA: |
miR-760 |
| Biological function: |
Suppresses ovarian cancer progression by inhibiting cell proliferation and migration and suppressing tumor growth. |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-760, thereby regulating SOCS3 expression. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); metastasis (inhibits); ceRNA regulation (promotes); JAK/STAT (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; FISH / smFISH; Luciferase Reporter Assay; Bioinformatics Analysis; Transfection; CCK8; Colony Formation Assay; Transwell Assay; In Vivo Animal Model |
| Clinical significance: |
hsa_circ_0007874 is a promising OVA prognostic biomarker. |
| Description: |
hsa_circ_0007874 is downregulated in ovarian cancer cell lines and functions as a tumor suppressor. Its overexpression inhibits proliferation, migration, and xenograft tumor growth by sponging miR-760 and relieving repression of SOCS3 (hsa_circ_0007874/miR-760/SOCS3 axis). |
| Confidence score: |
0.5979 |