| Expression pattern: |
UP |
| Associated gene: |
TRIM25, IGF2BP3 |
| Associated microRNA: |
miR-127-5p |
| Biological function: |
Promotes HCC cell proliferation and migration/invasion; enhances tumor growth in vivo. |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-127-5p, thereby modulating TRIM25 and IGF2BP3 expression; interactions confirmed by luciferase reporter assays. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Transwell Assay; In Vivo Animal Model |
| Clinical significance: |
Potential therapeutic target; suggested as a prognostic biomarker (suggestive statement). |
| Description: |
hsa_circ_0026134 is up-regulated in HCC tissues and cell lines and functions as an oncogenic circRNA. It sponges miR-127-5p to increase TRIM25 and IGF2BP3, thereby promoting HCC cell proliferation and migration/invasion and supporting xenograft tumor growth. |
| Confidence score: |
0.5607 |