circRNA basic information
circBase ID: hsa_circ_0026134
Name: hsa_circ_TUBA1C
Synonym: circRNA TUBA1C
Host Gene: TUBA1C
Genomic location(hg19): chr12:49658864-49667113:+
Genomic location(hg38): chr12:49265081-49273330:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

HCC tissue samples; adjacent noncancerous tissue samples
Cell lines:

HepG2; HepaRG; LM3; SK-Hep1; LO-2
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: TRIM25, IGF2BP3
Associated microRNA: miR-127-5p
Biological function: Promotes HCC cell proliferation and migration/invasion; enhances tumor growth in vivo.
Molecular mechanism: Acts as a miRNA sponge for miR-127-5p, thereby modulating TRIM25 and IGF2BP3 expression; interactions confirmed by luciferase reporter assays.
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Transwell Assay; In Vivo Animal Model
Clinical significance:

Potential therapeutic target; suggested as a prognostic biomarker (suggestive statement).
Description:

hsa_circ_0026134 is up-regulated in HCC tissues and cell lines and functions as an oncogenic circRNA. It sponges miR-127-5p to increase TRIM25 and IGF2BP3, thereby promoting HCC cell proliferation and migration/invasion and supporting xenograft tumor growth.
Confidence score:

0.5607
Other information
Title:

Hsa_circ_0026134 expression promoted TRIM25- and IGF2BP3-mediated hepatocellular carcinoma cell proliferation and invasion via sponging miR-127-5p.

Journal: Bioscience reports
Published: 2020
PubMed ID: 32648571
Study type:

combined biological and clinical study
Data availability: -
Code availability: -