circRNA basic information
circBase ID: hsa_circ_0007874
Name: hsa_circ_MTO1
Synonym: -
Host Gene: MTO1
Genomic location(hg19): chr6:74175931-74176329:+
Genomic location(hg38): chr6:73466208-73466606:+
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0008170
MONDO name: ovarian cancer
Disease details: ovarian cancer
Disease DO ID:
 2394
Disease MeSH ID:
 D010051
Disease NCIt ID:
 C7431
Disease ICD11 ID:
 685124533
Disease OMIM ID:
 167000
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissues
Cell lines:

IGROV1; A2780; ES-2; OV2008; SKOV3; ISOE80; HEK239T; HEK293T
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
DN
Associated gene: SOCS3
Associated microRNA: miR-760
Biological function: Suppresses ovarian cancer progression by inhibiting cell proliferation and migration and suppressing tumor growth.
Molecular mechanism: Acts as a miRNA sponge for miR-760, thereby regulating SOCS3 expression.
Biological pathway or process:

proliferation (inhibits); migration (inhibits); metastasis (inhibits); ceRNA regulation (promotes); JAK/STAT (other)
Detected method:
Q
Validation methods:

RT-qPCR; FISH / smFISH; Luciferase Reporter Assay; Bioinformatics Analysis; Transfection; CCK8; Colony Formation Assay; Transwell Assay; In Vivo Animal Model
Clinical significance:

hsa_circ_0007874 is a promising OVA prognostic biomarker.
Description:

hsa_circ_0007874 is downregulated in ovarian cancer cell lines and functions as a tumor suppressor. Its overexpression inhibits proliferation, migration, and xenograft tumor growth by sponging miR-760 and relieving repression of SOCS3 (hsa_circ_0007874/miR-760/SOCS3 axis).
Confidence score:

0.5979
Other information
Title:

Upregulation of hsa_circ_0007874 suppresses the progression of ovarian cancer by regulating the miR-760/SOCS3 pathway.

Journal: Cancer medicine
Published: 2020
PubMed ID: 32023009
Study type:

biological research
Data availability: -
Code availability: -