| Expression pattern: |
UP |
| Associated gene: |
HEY1 |
| Associated microRNA: |
miR-138-5p |
| Biological function: |
Promotes CRC cell viability/proliferation and aerobic glycolysis and inhibits apoptosis; attenuates lidocaine anti-tumor effects. |
| Molecular mechanism: |
circHOMER1 acts as a sponge for miR-138-5p to regulate HEY1 expression (ceRNA mechanism) in CRC cells, affecting proliferation/apoptosis and aerobic glycolysis under lidocaine treatment. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); glycolysis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Luciferase Reporter Assay; Transfection; CCK8; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model; Bioinformatics Analysis; Clinical Sample Validation |
| Clinical significance: |
Higher circHOMER1 expression was correlated with lymph node metastasis and advanced TNM stages in CRC patients. |
| Description: |
circHOMER1 is up-regulated in colorectal cancer tissues and cell lines. It promotes malignant phenotypes by sponging miR-138-5p to increase HEY1 expression, thereby supporting proliferation and aerobic glycolysis and reducing apoptosis; lidocaine counteracts CRC partly by down-regulating circHOMER1 and modulating the circHOMER1/miR-138-5p/HEY1 axis. |
| Confidence score: |
0.6521 |