| Expression pattern: |
DN |
| Associated gene: |
DKK3, beta-catenin, c-myc |
| Associated microRNA: |
miR-626 |
| Biological function: |
Suppresses HCC cell proliferation and migration; inhibits xenograft tumor growth |
| Molecular mechanism: |
Acts as a ceRNA/miRNA sponge for miR-626 to upregulate DKK3 and inactivate Wnt/beta-catenin signaling (reducing beta-catenin/TCF activity and downstream targets such as c-myc). |
| Biological pathway or process: |
Wnt/beta-catenin (inhibits); proliferation (inhibits); migration (inhibits); invasion (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; RNA Pull-Down; Transfection; MTT; Colony Formation Assay; Transwell Assay; Wound Healing Assay; Western Blot; In Vivo Animal Model; H&E Staining |
| Clinical significance: |
Down-regulation in tumor tissues was more common in bigger tumor size group (≥5cm). |
| Description: |
hsa_circ_0004018 is down-regulated in HCC tissues and cell lines and suppresses HCC proliferation/migration and xenograft growth. Mechanistically, it sponges miR-626 to relieve repression of DKK3, thereby inhibiting Wnt/beta-catenin signaling (reduced beta-catenin/TCF activity and c-myc). |
| Confidence score: |
0.7052 |