| Expression pattern: |
UP |
| Associated gene: |
PNN |
| Associated microRNA: |
miR-330-3p |
| Biological function: |
promotes cell proliferation, viability, invasion and adhesion; inhibits apoptosis |
| Molecular mechanism: |
ceRNA sponging of miR-330-3p to upregulate PNN |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); invasion (promotes); migration (other); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Transfection; BrdU; CCK8; Annexin V/PI Flow Cytometry; Transwell Assay; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; Bioinformatics Analysis; Clinical Sample Validation; Microarray |
| Clinical significance: |
- |
| Description: |
circ_0032463 is up-regulated in osteosarcoma tissues and cell lines and promotes malignant phenotypes (proliferation/viability/invasion/adhesion) while inhibiting apoptosis. Mechanistically, it acts as a ceRNA that sponges miR-330-3p, thereby relieving repression of PNN and promoting OS progression. |
| Confidence score: |
0.8058 |