| Expression pattern: |
UP |
| Associated gene: |
KLF12, Argonaute2 |
| Associated microRNA: |
miR-370 |
| Biological function: |
Promotes OS/DXR cell proliferation, migration and invasion; inhibits apoptosis; increases doxorubicin resistance (reduces DXR sensitivity); promotes tumor growth in vivo. |
| Molecular mechanism: |
Acts as a ceRNA/miRNA sponge for miR-370 to de-repress KLF12, thereby promoting tumorigenesis and doxorubicin chemoresistance. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); drug resistance (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
Higher circ_0003496 expression is associated with doxorubicin-resistant (chemoresistant/recurrent) osteosarcoma tissues versus chemosensitive primary tissues. |
| Description: |
hsa_circ_0003496 (circ_0003496) is up-regulated in doxorubicin-chemoresistant osteosarcoma tissues and DXR-resistant OS cell lines. Functionally, it promotes proliferation/migration/invasion, inhibits apoptosis, increases MDR-related proteins, and enhances DXR resistance. Mechanistically, it acts as a miR-370 sponge to de-repress KLF12 (circ_0003496/miR-370/KLF12 axis). |
| Confidence score: |
0.7289 |