| Expression pattern: |
UP |
| Associated gene: |
CPEB4, HK2 |
| Associated microRNA: |
miR-145-5p |
| Biological function: |
Promotes glioma cell proliferation, migration, invasion, glycolysis and tumor growth; inhibits apoptosis. |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-145-5p, thereby regulating the miR-145-5p target CPEB4 (ceRNA-like mechanism). |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); glycolysis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Actinomycin D / DRB Stability Assay; RNase R Treatment; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; MTT; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; Clinical Sample Validation; In Vivo Animal Model; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
CircTTBK2 level was associated with poor survival of glioma patients. |
| Description: |
circTTBK2 is up-regulated in glioma and associated with poorer patient survival. Functionally, circTTBK2 promotes proliferation, migration/invasion, glycolysis and in vivo tumor growth while inhibiting apoptosis, mainly by sponging miR-145-5p to increase CPEB4 expression. |
| Confidence score: |
0.8295 |