| Expression pattern: |
UP |
| Associated gene: |
PFKFB2 |
| Associated microRNA: |
miR-646 |
| Biological function: |
Facilitates proliferation, migration/invasion (metastasis), and glycolysis, and inhibits apoptosis of gastric cancer cells; promotes tumor growth in vivo. |
| Molecular mechanism: |
circFLNA acts as a miRNA sponge for miR-646 to regulate PFKFB2. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); glycolysis (promotes); apoptosis (inhibits); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; CCK8; Transwell Assay; Annexin V/PI Flow Cytometry; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; Western Blot; In Vivo Animal Model; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High circFLNA expression was significantly associated with the poor prognosis of GC patients; circFLNA might be a potential biomarker for GC treatment. |
| Description: |
circFLNA is up-regulated in gastric cancer and promotes malignant phenotypes (proliferation, migration/invasion, glycolysis) while inhibiting apoptosis. Mechanistically, it functions as a ceRNA by sponging miR-646 to increase PFKFB2, thereby facilitating GC progression and tumor growth in vivo. |
| Confidence score: |
0.7548 |